Correlation between pre-treatment serum testosterone and ISUP grade group in patients with cancer of the prostate in NAUTH Nnewi Department:Community Health By: godstimearinze Project ID: 7402 Rating: (5.0) votes: 1 Price:₦3000 Get the Complete MaterialAbstractProstate cancer (PCa) is a global health burden with risk factors including race, age, genetics, environment, and lifestyle. PCa exhibits diverse phenotypes from indolent to aggressive life-threatening forms. Early detection enables better outcomes, but historic tumor markers lacked adequate sensitivity and specificity until prostate specific antigen (PSA). However, PSA does not reliably distinguish aggressive cancers. Thus the Gleason and subsequent International Society for Urological Pathology (ISUP) grading systems emerged to categorize tumors by aggressiveness. However, biopsy and treatment carry complications that may outweigh the benefits for latent tumors. Ongoing research seeks markers to predict PCa aggressiveness. Serum testosterone (T) shows promise but studies conflict regarding its influence on PCa development and progression. This hospital-based cross-sectional study will correlate pre-treatment T levels with ISUP grade among 72 purposively sampled PCa patients at Nnamdi Azikiwe University Teaching Hospital, pending ethics approval and informed consent. The Statistical Product and Service Solutions version 23 will analyze the results. The study will elucidate the association between T and PCa aggressiveness in this understudied population. If T links to high-grade tumors, it could serve as an affordable predictor of patients needing more aggressive management, preventing overtreatment of indolent cases. Understanding specific drivers of PCa aggressiveness can guide clinical decision-making and resource allocation to match disease severity....Preview Download Preview +Other Community Health project topics and materials you might be interested in»Knowledge and awareness of the effects of narcotic drug use among students of Federal Polytechnic Idah»Effect of immunization in children between the ages of 0-5 in family health centre Idah Local Government Area Kogi State»The effect of abortion on female students in College of Health Sciences and Technology Idah, Kogi»Factors influencing the attitude of women towards family planning - case study of Oke Eiri, Atan Local Government Area»Problem of pregnancy and abortion on girl child education in Nigeria»Effect of malnutrition among children under five years of age in Patigi community of Patigi local government area of Kwara state»Attitude of couple toward modern family planning practice in Birnin Gwari, Birnin Gwari local government, Kaduna state»Importance of exclusive breast feeding on the health of an infant - case study of Idah local government area of Kogi state»Knowledge of protein energy malnutrition and its prevention among mothers with children below five years of age in Ubiegbe Community Idah, Lga, Kogi state»Causes, effects and control of communicable diseases in secondary schools»The impact of community health works in elderly condition in Ungogo local government»Causes and effects of drug abuse among adolescent in Amede community»A study on the causes, effects, prevention and control of threatened abortion among childbearing mothers ages (18-45) years in Gilead Children Hospital»Assessment of prevalence malaria among the patients attending Tofa comprehensive hospital»Assessing the mother knowledge on the benefit of breast feeding among children 0 - 24 months - a case study of Matoya village Maigatari local government, Jigawa state