Effect of ethanolic extract of mature on Andrographis Paniculata king of bitters leaves on Gamma Glutamyl Transferase activity in plasma of ccl4 induced hepatotoxic albino rats Department:Biochemistry By: Ayodeji1224 Project ID: 8349 Rating: (5.0) votes: 1 Price:₦4000 Get the Complete MaterialAbstractIn traditional systems of medicine, many plants were used as cure for liver problems. Medicinal plants possess valuable bioactive compounds that protect humans from various complications. Andographis paniculata is one such plant that was used quite often inthe traditional system of this medicine. The objective of this work is to investigate the ameliorative effect of ethanolic extract of Andographis paniculata leaf on CCL4 -induced hepatotoxic rats. Thirty adult male Wistar rats were used for this study. They were divided into 6 groups as follows: Group 1 (the control) (n 5) received distilled water daily ad libtum for the whole period of the study. Group 2 (hepatotoxic control) (n 5) received 1.5 ml/kg/day of CCL4 for single administration. Groups 3, 4 and 5 (n 5) received CCL4 after which they received 50, 100 and 200 mg/kg/day each of Andographis paniculata orally respectively. Group 6 (n 5) received Andographis paniculata and in addition, received 200 mg/kg/day each of silymarin orally respectively, for fourteen days. Marker of liver function, such as Gamma glutamyl transferases was determined in the plasma. CCL4 treatment induced significant (P - 0.05) increases in plasma Gamma glutamyl transferase activity in the toxic control when compared to the normal control group. Post-treatment with Andographis paniculata caused significant (p 0.05) decreases in Gamma glutamyl transferase activty in the treated groups when compared with the toxic control group. The results of this study indicated that Andographis paniculata ameliorated the abnormalities caused by CCL4 in rats. Hence, the extract has the potential of being used for the management of liver damage....Preview Download Preview +Other Biochemistry project topics and materials you might be interested in»Phytochemical and nutritive composition of fluted pumpkin»Determination of ascorbic acid in selected fruits mango, orange and pineapple using spectro-photometric method»Comparative evaluation of heavy metal loads in some selected soft drinks in Owerri, Imo state»Antilipidemic effect of water (H2O) extract of desmodium velutinum leaves on albino Wistar rats»The effect of water extract of cola nitida pod on lipoprotein concentrations of albino Wistar rats»Preliminary investigation on effects of burantashi extract on lipoproteins of albino male and female whistar rats»The extraction of manganese (iv) ion from aqueous media using 1-phethyl-3-methyl pyrazolone-5»Nutritive value, anti-nutrient and mineral composition of cashew nut (Anacardium Occidentale)»Evaluation of the immunomodulatory effect of oral administration of the methanol extract of gongronema latifolium (utazi) in wistar albino rats»Comparative study on the free radical scavenging potential of turmeric and beetroot»Phytochemicals and minerals analysis of rosary pea (Abrus Precatorious leaves)»Determination of total petroleum hydrocarbons in Niger river»Qualitative phytochemical and gas chromatography mass spectrometry GCMS of Nhexane extracted leaves of sabicea calycina»Charges in the concentration of nitric oxide in the serum gills brain liver and kidney of clarias gariepinus exposed to glyphosatebased herbicide»Hydrogen peroxide scavenging activities and reducing power of various fruits juice in Yenagoa