Effects of Levonorgastrel on the function of Wistar rats treated with Datura Stramonium extracts Department:Biochemistry By: SIRJOSEPH Project ID: 8481 Rating: (5.0) votes: 1 Price:₦4000 Get the Complete MaterialAbstractThe recent study investigated the effects of methanol extract of Datura stramonium leaves on levonorgestrel-induced toxicity in albino rats. Renal parameters (sodium and potassium) were estimated in order to investigate the toxic effect of levonorgestrel and the ameliorating effects of the extract. Twenty (20) rats grouped in to five (n4) were administered levonorgastrel and methanol leaves extract based on the experimental design. The albino rats were sacrificed after the experimental period of fourteen (14) days, and blood was collected for estimation of the renal function by ocular puncture. The administration of levonorgestrel significantly (p0.05) decreased the blood serum of sodium and potassium levels (from 254.91 ± 216.56 and 4.28 ± 0.07) group 1, to (112.04 ± 74.71 and 3.49 ± 2.34) in group 2, respectively, when rats were administered with levonorgestrel toxicity. The administration of the levonorgestrel alone side with the plant extract at 100mg/kg, resulted to a significantly (p0.05) increase in the serum blood levels of potassium (5.22 ± 0.18) and sodium (147.93 ± 2.04). Upon an increase in the concentration of the extract to 200mg/kg results in serum blood levels of potassium and sodium (2.66 ± 3.07 and 72.93 ± 04.22), respectively. A further increase in the concentration of the extract to 300mg/kg improves the level of sodium (148.16 ± 1. 50) and potassium (5.06 ± 0.27). The findings of this study can be concluded that the methanol leaves extract of Datura stramonium showed potential in correcting the effects induced by levonorgestrel intoxication. ...Preview Download Preview +Other Biochemistry project topics and materials you might be interested in»Phytochemical and nutritive composition of fluted pumpkin»Determination of ascorbic acid in selected fruits mango, orange and pineapple using spectro-photometric method»Comparative evaluation of heavy metal loads in some selected soft drinks in Owerri, Imo state»Preliminary investigation on effects of burantashi extract on lipoproteins of albino male and female whistar rats»Antilipidemic effect of water (H2O) extract of desmodium velutinum leaves on albino Wistar rats»The effect of water extract of cola nitida pod on lipoprotein concentrations of albino Wistar rats»Nutritive value, anti-nutrient and mineral composition of cashew nut (Anacardium Occidentale)»The extraction of manganese (iv) ion from aqueous media using 1-phethyl-3-methyl pyrazolone-5»Evaluation of the immunomodulatory effect of oral administration of the methanol extract of gongronema latifolium (utazi) in wistar albino rats»Comparative study on the free radical scavenging potential of turmeric and beetroot»Phytochemicals and minerals analysis of rosary pea (Abrus Precatorious leaves)»Determination of total petroleum hydrocarbons in Niger river»Qualitative phytochemical and gas chromatography mass spectrometry GCMS of Nhexane extracted leaves of sabicea calycina»Charges in the concentration of nitric oxide in the serum gills brain liver and kidney of clarias gariepinus exposed to glyphosatebased herbicide»Hydrogen peroxide scavenging activities and reducing power of various fruits juice in Yenagoa